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生物通
26 天
癌症中的AXL信号:从分子洞察到靶向治疗
AXL 是 TAM 受体家族的成员,已成为晚期人类恶性肿瘤的潜在治疗靶点。它在多种癌症中频繁过表达,并在多种促肿瘤通路中发挥重要作用,这些通路包括癌细胞增殖、侵袭、转移、上皮 - 间质转化(EMT)、血管生成、肿瘤干细胞特性维持、DNA 损伤应答、获得性 ...
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