Investigators from Duke University hypothesized that hirudin-like protease inhibitors could be generated by linking exosite-binding aptamers with small-molecule active site inhibitors, thus generating ...

However, the potency of aptamers is often limited as they do not directly inhibit the catalytic sites on their targeted proteases. The natural anticoagulant hirudin achieves potent activity by ...

Medications for PE fall into two categories: blood thinners (anticoagulants) and clot-dissolvers (thrombolytics). These two classes of medications serve completely different purposes ...

School of Rare Earth, University of Science and Technology of China, Hefei 230026, China ...

• Adjust starting time of warfarin based on CrCl as follows: º CrCl ≥50mL/min: Start warfarin 3 days before discontinuing dabigatran º CrCl 30−50mL/min: Start warfarin 2 days before ...

Trials of direct oral anticoagulants for atrial fibrillation have excluded patients with acute ischaemic stroke because of concerns over the risk of haemorrhagic transformation of the acute infarct.

The community pharmacy oral anticoagulant safety audit was conducted as part of the 2021/2022 pharmacy quality scheme (PQS). 9,303 pharmacies participated in this audit and submitted data for 131,526 ...