Third, activation of GPER-1 by molecules that mimic estrogen structure, such as xenoestrogens (e.g., Bisphenol A), poses a potential risk of endocrine disruption. Finally, the interaction of GPER-1 ...

Current research is exploring various anti-obesity drugs and compounds that target these signaling pathways, offering hope for more effective treatments in the future. Adipose Tissue: A type of ...

Background: Obesity is associated with dysregulated metabolism and low-grade chronic inflammation in adipose tissue (AT). Immune cells ... regulator of M-MDSCs and CXCR3 expressing CD8 + T cells ...

H 2 S generated by adipose tissues regulates the local insulin sensitivity. H 2 S can act as an 'adipocytes-derived relaxing factor' in aortic periadventitial adipose tissues. H 2 S plays ...

The prevalence of obesity and overweight is increasing rapidly and functional brown adipose tissue (BAT), with its role in energy expenditure, may provide one solution. However, several key ...

In cancer-associated cachexia, elevated TNF-α and IL-6 exacerbate muscle and fat loss by regulating multiple metabolic signaling pathways ... and NF-kB/HSL to reduce adipose degradation and ...

Then, we studied the signalling pathways involved and compared the results obtained in mice to human. Results We found that modulating the gut microbiota with prebiotics modifies the actions of ...

Homeostatic hunger is triggered by food deprivation and involves neuroendocrine, endocrine ... reprogramming of endocrine and neurologic signaling that controls energy balance, physical exercise ...