Scientists speculate that Semaglutide, as a GLP-1 receptor analog, represents a peptide with broad research potential beyond ...

SNAP specifically dephosphorylates the PHLPP1 targets p-S6K and p-AKT (downstream of mTOR and AMPK respectively) in fibroblasts cultured in hypoxic and low-glucose conditions for 3 days, significantly ...

Department of Thoracic Surgery, Sichuan Clinical Research Center for Cancer, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, Affiliated Cancer Hospital of the University of Electronic ...

Damaged or superfluous proteins and other components inside a cell are broken down in a process called autophagy. Aging research has established that autophagy pathways become less active with age ...

Here, we show that Tda1, the yeast ortholog of human Nuak1, is a direct kinase for H3pT11 upon low glucose stress. Yeast AMP-activated protein kinase (AMPK) directly phosphorylates Tda1 to govern Tda1 ...

We further show that LD consumption in cells undergoing acute glucose starvation occurs by the process of micro-autophagy of LDs (i.e. µ-lipophagy), which is dependent on AMPK activation and core ...