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25 天
铁死亡的“天敌”:GPX4棕榈酰化调节机制的创新发现
GPX4棕榈酰化和去棕榈酰化调控铁突变 02 为了进一步验证2-BP和ML349通过靶向GPX4来调节铁蛋白沉积的敏感性,团队生成了GPX4基因敲除的A375细胞,然后将这些细胞皮下注射到裸鼠体内进行异种移植试验。用IKE单独或与2-BP或ML349联合治疗A375 GPX4-KO异种移植肿瘤 ...
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