Selecting an appropriate mouse model is one ... The development of humanized mice, animal models that support growth of human immune cells, soon followed. The generation of animal models capable ...

In a recent publication, researchers from Colorado State University presented the development and evaluation of humanized mice as a hybrid dual-use model for testing therapeutics against both HIV and ...

If on hearing “humanized mouse” you think Stewart Little, your imagination has taken you a bit too far. Imagine instead a mouse with a human gene. The goal of humanizing a mouse is to model ...

2006. Enhanced half-life of genetically engineered human IgG1 antibodies in a humanized FcRn mouse model: potential application in humorally mediated autoimmune disease. Int Immunol 18:1759-69.

Next-generation mouse models provide opportunities to understand the role of humanized genes in pathology and cognitive function. We are developing a fully translational platform for testing how these ...

These differences are relevant to selecting the most appropriate HIS model for longer-term studies. View this webinar presentation to: Review key host strains used to develop humanized immune system ...