The molecular basis of phospho-tyrosyl-regulation of Src-family and Syk-family protein tyrosine kinases in signaling pathways is a current focus of the lab ... We are also actively investigating the ...

The ERBB receptors are a group of receptor tyrosine kinases (RTKs) involved in key cellular functions including cell growth and survival. What are the activation mechanisms particular to ERBBs?

Eph receptor tyrosine kinases are involved in many cellular processes, including axon guidance, cell migration and angiogenesis. Like many other receptor tyrosine kinases, the Eph receptors are ...

All JAK kinases are tyrosine kinases and all are also Janus ... Zoler and colleagues have demonstrated that receptor-binding competition among members of the Janus kinase family may explain ...

Sorafenib is an oral multikinase inhibitor that inhibits tumor growth and proliferation by interfering with several receptor tyrosine kinases involved in the pathogenesis and perpetuation of ...