T-cell therapy, originally developed for haematological malignancies, has recently emerged as a promising therapy for ...

Findings suggest targeting neuro-immune pathway could lead to strategies for managing diabetes, obesity or some types of ...

The aim of this study is to investigate the role of somatostatinergic and cytokine signalling in hepatic stellate cells (HSC), the effector cells of hepatic fibrosis. Methods The production of ...

Results Clinical-grade tolDCs established from patients with RA exhibit a typical tolerogenic phenotype of reduced costimulatory molecules, low production of proinflammatory cytokines and impaired ...

HMOs influence gut-associated lymphoid tissue (GALT) by interacting with receptors on enterocytes and immune cells, leading to the release of cytokines such as TNF-α, IL-6, and IL-10. HMOs also ...

A new paper by a team of Concordia researchers from the departments of Biology and Physics proposes a novel method of ...

The study proposes the immune system as a major regulator of blood sugar. The functions of hormones like insulin and glucagon ...

Immune cells unexpectedly regulate blood sugar levels, offering new insights for managing diabetes, obesity, and cancer.

When we think about the immune system, we usually associate it with fighting infections. However, a study published in Science by the Champalimaud Foundation reveals a surprising new role.

The mechanism of action of CIs is blocking the intracellular T cell signals responsible for the production of cytokines (Figures 4 and 5). While CsA and TAC depend on different intracellular ...

Although still preliminary, the involvement of cytokine signalling loops in pre-malignant cell-fate decisions, as well as the defects in cytokine-receptor modules seen in later stages of cancer ...