Another critical aspect of applying encapsulation to sorting cytokine-secreting cells is the ability to recover the cells in a viable and functionally normal state. Thus, PBMC were encapsulated ...

Findings from these systems indicate that chemokines have indirect effects on T cell differentiation through effects on APC trafficking or cytokine secretion, as well as direct effects through ...

1,2 (2) Engineered CAR T cells expressing therapeutic payloads can transform the immunosuppressive environment of solid tumors, such as through producing and secreting proinflammatory cytokines. 3,4 ...

The study analyzed both immunological (receptor activation, cytokine secretion, T-cell modulation) and metabolic parameters (metabolic state) in dendritic cells—specific immune cells—derived ...

IN8bio (INAB) unveiled INB-600, its next generation gammadelta T cell-based TCE platform. It is designed to address one of the biggest ...

CAR-T cell therapy is currently used successfully ... it results in lower pro-inflammatory cytokine secretion." Ferreira noted that the team also made sure to run tests on both naive Tregs and ...

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The platform’s first candidate, INB-619, targets CD19, a key marker broadly found on B cells, which play a central role in leukemias, lymphomas, and autoimmune diseases. In preclinical models, INB-619 ...

Cytokines are small proteins released by many different cells in the body, including those of the immune system where they coordinate the body’s response against infection and trigger inflammation.

T helper 17 (Th17) cells generate the pro-inflammatory cytokine interleukin-17 (IL17/IL17A). IL17 has been a target for a variety of therapeutic monoclonal antibodies and inhibitors to treat ...