pseudobulbar palsy, axial parkinsonism, supranuclear vertical gaze palsy, executive dysfunction, apathy, disinhibition and bradyphrenia. Corticobasal degeneration (CBD) is characterized by either ...

Patients with PSP often had severe postural instability at onset, symmetric parkinsonism, vertical supranuclear gaze palsy, speech and frontal lobe-type features. In contrast with PSP, the ...

The most specific diagnostic feature is the supranuclear vertical gaze palsy (inability to look up and down). Difficulty moving one's eyes in the downward direction is particularly suggestive of the ...

More information: Miriam Scarpa et al, Post mortem validation and mechanistic study of UCB‐J in progressive supranuclear palsy patients' brains, Alzheimer's & Dementia (2024). DOI: 10.1002/alz.14409 ...

and cerebral cortex of patients with progressive supranuclear palsy (PSP). This group has now shown that a low ratio of these tau forms reliably differentiates patients with PSP from controls and ...

The additional symptoms and signs may include inability to look up and down (vertical gaze palsy) and early postural instability leading to frequent backward falls, such as seen in progressive ...