Ultimately, through control of cell-wide acetylation (and downstream signaling cascades), these enzymes are involved in a myriad of human diseases, and targeted epigenetic discovery efforts can ...

The histone deacetylases HDAC type I (1-3) and the family of Sirtuins type III, have been identified to mediate protein delactylation (Moreno-Yruela et al, 2022). Next, we determined which ...

univ-lorraine.fr Background Methyl donor deficiency (MDD) aggravates experimental colitis in rats and increases endoplasmic reticulum (ER) stress through decreased sirtuin 1 (SIRT1) in neuronal cells ...

This important study shows that soluble uric acid is an endogenous inhibitor of CD38, a regulator of inflammatory responses. The convincing evidence draws both on biochemical analyses and in vivo ...

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. Sepsis is a heterogeneous syndrome resulting ...

Background Genomic screening uncovered interferon-gamma (IFNγ) pathway defects in tumours refractory to immune checkpoint blockade (ICB). However, its non-mutational regulation and reversibility for ...

Nutrient-sensing signaling is an integrated network of multiple pathways, including the IIS (insulin/IGF-1) pathway, AMPK (adenosine monophosphate (AMP)-activated protein kinase), mTOR, Sirtuins, and ...