In the ever-growing world of longevity research, one name that has gained significant attention is Nicotine Mononucleotide (NMN). This compound, once considered just a minor player in biochemistry, ha ...

Nuclear Sirtuin 6 (SIRT6) plays essential roles in gene transcriptional ... We hypothesize Sirt 6 deficiency causes coronary endothelial dysfunction and contributes to CMD; activating Sirt6 will ...

Department of Applied Chemistry, Center for Bionano Intelligence Education and Research, Hanyang University ERICA, 55 Hanyangdaehak-ro, Sangnok-gu, Ansan-si, Gyeonggi-do 15588, Republic of Korea ...

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Nguyen, H.; Johnson, S.; Zhang, X.; Pin, S.; Lim, J.; Zhang, D.

The successful conversion of the immune-excluded into an inflamed immunotype through epigenetic activation of STAT1-GSDME pyroptotic circuitry provides a mechanistic basis of CXD101 plus anti-PD-1 ...

CA activators (CAAs) participate in the enzyme catalytic cycle by facilitating the rate-determining step: a release of a proton from the zinc-coordinated water molecule to the reaction medium.