Studies indicate that intracellular calcium overload in AP leads to mitochondrial dysfunction, disrupting ATP synthesis and causing acinar cell damage and necrosis, exacerbating inflammation (16–18).

Results Reg4 mRNA and protein were markedly upregulated during arginine-induced pancreatitis. Reg4 was widely expressed in residual acinar cells around the islets and regenerating metaplastic ...

Dec. 18, 2024 — Scientists have generated human stem cell models which contain notochord -- a tissue in the developing embryo that acts like a navigation system, directing cells where to build ...

Here, we review the recent literature on how single-cell transcriptomic approaches have changed our understanding of pancreas biology and disease progression. The exocrine pancreas has more epithelial ...

Stem cells are cells that have the capacity to self-renew by dividing and to develop into more mature, specialised cells. Stem cells can be unipotent, multipotent, pluripotent or totipotent ...

GlobalData tracks drug-specific phase transition and likelihood of approval scores, in addition to indication benchmarks based off 18 years of historical drug development data. Attributes of the drug, ...

Olaparib is under clinical development by AstraZeneca and currently in Phase II for Malignant Mesothelioma. According to GlobalData, Phase II drugs for Malignant Mesothelioma have a 42% phase ...

To discover how brain cells respond to microgravity, scientists sent tiny clumps of stem-cell derived brain cells called 'organoids' to the International Space Station. Microgravity is known to ...

Endometrial large-cell neuroendocrine carcinoma admixed with a high-grade serous (HGS) adenocarcinoma is extremely rare with only one reported case in the literature. We present the second reported ...

CD4 T helper cells are a type of white blood cell called a lymphocyte that serves an important role in your immune system. These cells help defend the body against infection by directing other "killer ...