Subsequently, the rat stem cells differentiate and form the ... “Being able to generate brain tissues from one species inside another can help us understand brain development and evolution ...

Gross pathological findings were not remarkable; no notable macroscopic lesions were observed in the brain of any animal. Protocol-required tissues and ... high-dose female rat had a large focus ...

Organoids are three-dimensional tissue cultures grown in vitro from stem cells ... the organoid had to form connections with the rest of the rat’s brain, and it also had to do something functional to ...

Uniform protein labeling in intact tissues is a challenge. An approach that allows antibodies to seep within organs could ...

and found that while 60% of the cells in the mature mice ended up having rat origin, the animals acted like typical lab mice. By growing brain tissues from one species inside another, scientists ...

This requires injecting substances or implanting a small diode into the brain in order to conduct light pulses into the tissue or to read the activity of individual brain cells ... Using 3D-printed ...

letting the antibodies permeate the tissue, and then turning binding back on. Staining of neurons (cyan) across an entire intact rat brain. Credit: Chung Lab/MIT Picower Institute As well as it ...