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The effective targeting of RAS-mutant acute myeloid leukemia (AML) still remains a challenge; RAS mutations are tied to relapse to targeted therapy, such as resistance to FLT3 inhibitors due to the ...

Additionally, FTase inhibitors have shown efficacy in preclinical studies for the treatment of neurofibromatosis type 1 (NF1), a genetic disorder characterized by Ras pathway dysregulation.

In the "on" position, the oncogene activates critical cell signaling pathways involving cell proliferation ... "The small molecules identified here represent the first generation of Ras inhibitors ...

There are no approved RAS-ON inhibiting drugs on the market today; therefore, Revolution faces a challenge to convert the obvious promise of targeting and inhibiting a signalling pathway whose ...

Several subsequent studies have confirmed this post-MI benefit of RAS inhibition ... as compared to ACE inhibitors since ARBs might block angiotensin II formed by non-ACE pathways and the negative ...

Bayer announced today initiation of a Phase I clinical trial with BAY3498264, an investigational oral selective Son of Sevenless Homologue 1 (SOS1) inhibitor. The open-label, first-in-human, dose ...

Verastem Oncology (Nasdaq: VSTM), a biopharmaceutical company committed to advancing new medicines for patients with cancer, ...

Prescient Therapeutics Limited (AU:PTX) has released an update.Don't Miss Our Christmas Offers:Discover the latest stocks recommended by top ...

today announced key clinical updates from its RAS(ON) inhibitor portfolio. The data to be presented during an investor webcast today at 8:00 a.m. Eastern Time (ET) will focus on updated clinical ...