A110 is mutated to V110 and then the protein goes out of frame. E. Validation of Orc2 deletion 3 days after Adeno cre transduction. F. Western blot of ORC2 protein 5 days after Adeno cre transduction.

ROSA26 genotyping was carried out with primers F1 forward (common to both alleles ... PCR product was run on 2% agarose gel and WT band was detected at 650bp, and transgenic band at 340bp. Sox2-Cre ...

Conditional gene targeting based on excision or inversion of loxP-flanked DNA segments by Cre recombinase is a powerful technology for the analysis of gene function, but unexpected expression ...

Aicda-Cre-ERT2 x Rosa26-lox-STOP-lox-eYFP mice (20) were bred at the Centre d’Immuno-Phenomique, (Marseille, France), and transferred to the animal care facility of Centre d’Immunologie de ...

Objective We aim to unveil the consequences of mutant Gnas R201C expression on phenotype, transcriptomic profile and genomic dependencies. Data are available in a public, open access repository. Bulk ...

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Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. Neural stem cells (NSCs) can give rise to both ...

Miriam Wheeler, head of the global real estate financing group at Goldman Sachs (GS), said she doesn’t share concerns others in the CRE industry have voiced about Trump’s economic proposals such as ...

引言在生命科学研究中，探究基因的功能是解码生命奥秘的核心任务之一。然而，这项工作往往面临一个关键挑战：如何精准地比较携带突变基因的细胞与正常细胞的生物学差异。在传统研究中，研究人员通常通过独立的实验对象（如不同的实验动物）进行比较，然而，这种方法不可避免地受到外部因素如环境、表观遗传改变及组织微环境 ...

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. The NLRP3 inflammasome plays a pivotal role in ...