Researchers have developed a gene-editing treatment for prion disease that extends lifespan by about 50 percent in a mouse model of the fatal neurodegenerative condition. The treatment ...

Researchers at the Broad Institute of MIT and Harvard have developed a gene-editing treatment for prion disease that extends lifespan by about 50% in a mouse model of the fatal neurodegenerative ...

Dublin, Jan. 15, 2025 (GLOBE NEWSWIRE) -- The "Prion Disease Market Assessment: Epidemiology, Treatment Landscape, Unmet Needs, Emerging Therapies, and Value & Access" report has been added to ...

The treatment, which uses base editing to make a single-letter change in DNA, reduced levels of the disease-causing prion protein in the brain by as much as 60 percent.

Summary: A lipid anchor on nerve cell membranes stabilizes prion proteins (PrPC) and prevents their pathological aggregation into forms linked to prion diseases. Researchers developed new in vitro and ...

Those proteins then clump up in the brain and cause brain damage. Prion diseases, which include mad cow disease, are always fatal. In deer, the illness can exist for up to two years before symptoms ...

this has been termed a 'subversion of function'. If so, PrP C contributes to neurotoxicity in prion disease but by uncertain mechnisms.

preventing harmful aggregation linked to prion diseases. Their in vitro and cell culture models show how these anchors inhibit clumping, offering potential pathways for treatments targeting the ...

Topological confinement by a membrane anchor suppresses phase separation into protein aggregates: Implications for prion diseases. Proceedings of the National Academy of Sciences , 2024; 122 (1 ...

Researchers who late last week reported finding chronic wasting disease (CWD) prions in the muscles of infected moose, red deer, and reindeer in Norway say the discovery raises questions about the ...