Despite these differences, the authors found that chemotaxis and electrotaxis share a dependence on similar intracellular signaling molecules, most notably the phosphoinositide 3-kinase (PI3K ...

It is hoped that inhibitors for specific PI3K isoforms could also help to circumvent ... aided by the recent publication of the crystal structure of PI3Kδ alone and in complex with broad range ...

The current PI3K 3C inhibitors in use in advanced breast cancer are alpelisib and inavolisib. Capivasertib is an AKT inhibitor, which is also used in PI3K 3C mutated breast cancer. So these are ...

During autophagy, intracellular molecules and structures are sequestered within a membrane-bound structure known as an ...