In this respect, PI3K and mTOR positively regulate immune cell activation in neutrophils and mast cells. In plasmacytoid dendritic cells, these pathways have recently emerged as important regulators ...

Cordycepin, derived from fungi, shows promise in cancer therapy by inhibiting growth factor signaling pathways critical for ...

Their findings revealed a critical role for the PI3K-AKT-mTOR pathway, activated by platelet-derived growth factor (PDGF) secreted by macrophages and other innate immune cells. Fibroblasts in SSc skin ...

Dysregulated cell signaling underlies various diseases, emphasizing the importance of understanding these pathways for ...

In the absence of head-to-head studies, oncologists are looking across pivotal trials and are encouraged by Itovebi's safety and efficacy versus Piqray.

The top 10 most differentially upregulated mRNAs were identified by transcriptomics on the aorta, of these, Cytidine triphosphate synthase 1(CTPS1) was closely related to PI3K/AKT signaling pathway.

Both RTKs and Ras also activate PI3K-AKT pathway that affect cell survival and growth. Conventional PAKs (PAK1-3) phosphorylate c-Raf and contribute to its activation. Created with Biorender.com. (B) ...

【导读】由于缺乏有效的治疗手段，肝转移是结直肠癌（CRC）患者死亡的主要原因。 11月5日，北京大学崔一民教授研究团队在期刊《Advanced Science》上发表了题为“Targeting SLITRK4 Restrains ...

Abstract Title: Mechanism of action of gedatolisib in combination with fulvestrant and/or palbociclib in estrogen receptor ...