p53 is a common denominator among human cancers. How was it discovered? What are the persistent questions about its function? Aa Aa Aa It seems nearly impossible for a normal cell to become a ...

Arnold Levine and colleagues asked whether the function of the tumour suppressor p53 could also decline with age and hence contribute to enhanced mutation frequency and tumorigenesis ...

Our lab has had a long-standing interest in the role and regulation of the p53 tumor suppressor. Mutations in the p53 gene (TP53) are often associated with aggressive tumor behavior and poor patient ...

The findings were recently published in Communications Chemistry. p53 is central to the body's defense against cancer, tasked with regulating the cell cycle and triggering the death of damaged ...

The advent of large-scale sequencing in both development and disease has identified large numbers of candidate genes that may be linked to important phenotypes. Validating the function of these ...

A grim genealogy was constructed, and blood samples collected at family reunions. This effort, coupled with advances in molecular biology, led in 1990 to the identification of an underlying genetic ...

Unbiased professional product reviews from the experts at Digital Trends. We review TVs, laptops, phones, tablets, wearables, games, movies, and so much more. Our reviewers speak your language ...

Fakespot also filters out reviews it believes to be fake to produce a more reliable product rating. Amazon users give the Echo a 4.5-star rating, but after running it through Fakespot, the ...

That's why we invite any dealership customer who has had a car shopping or service experience to share their dealer review in our public forum. Every review is written by a real person ...

Sophie Kinsella, the author of “Confessions of a Shopaholic,” packs love, laughter and a harrowing real-life health ordeal into a 133-page novella. By Elisabeth Egan Suggested reading from ...

An Oct. 7 survival memoir and a chronicle of theft in 1948 grapple with the history of a war-torn region. By Max Strasser In “Diary of a Crisis,” Saul Friedländer takes the violence and ...

The Detransitioners is a special three-part series from National Review highlighting the stories of three young women who were driven down the rabbit hole of gender ideology by activist medical ...