Members of the nuclear receptor superfamily of transcription factors have important roles in modulating the responses of macrophages, microglia and lymphocytes to pro-inflammatory signalling ...

The superfamily of nuclear receptors can accommodate both relatively rigid ligands as well as conformationally flexible ligands. Examples of the influence of ligand shape and flexibility on the ...

此外，此前研究发现缺失 NR2F6 可增强 T 细胞的抗肿瘤反应，尤其是在免疫检查点抑制期间。本研究进一步表明，在 NK 细胞中缺失 NR2F6 对于缺乏有效 T 细胞表位或下调 MHC-I 表达以逃避免疫监视的肿瘤可能具有重要意义，为联合治疗干预提供了潜在途径。然而，NKp46 表达增强在自身免疫性疾病如系统性红斑狼疮（SLE）中的作用仍有待进一步研究，需要深入探讨 NK 细胞上 NKp46 ...

Work at the University of Florida has led to the identification of nuclear receptor subfamily 1 group D member 1 (Rev-erbA-α) antagonists reported to be useful for the treatment of cancer, sarcopenia ...