We investigated the expressions of hepatocyte transporters and nuclear receptors comprehensively in patients with early-stage and late-stage BA. These data provide evidence of how human liver ...

Dosage-sensitive sex reversal adrenal hypoplasia congenital critical region on X chromosome gene 1, DAX1, also known as NR0B1, is a less well characterized orphan nuclear receptor that has been ...

We are pleased to welcome Shawnte to our executive team to lead our Legal function as we progress both our late-stage palazestrant programs and our OP-3136 KAT6 program through clinical development,” ...

The p160 SRC family contains three homologous members, SRC1, SRC2 and SRC3, that interact with nuclear receptors and specific transcription factors. They recruit chromatin remodelling and other ...

Work at the University of Florida has led to the identification of nuclear receptor subfamily 1 group D member 1 (Rev-erbA-α) antagonists reported to be useful for the treatment of cancer, sarcopenia ...

Topical retinoids (for example, tretinoin) and retinoid analogues (for example, adapalene and tazarotene) help normalize hyperkeratinization and have demonstrated significant anti-inflammatory ...

Department of Paediatrics, Neonatal Pathology and Metabolic Bone Diseases, Medical University of Lodz, Poland ...

According to a new study published in the journal Cellular Signalling, cannabinoids may play a crucial role in preventing and ...

The bile salt, nuclear farnesoid X receptor (FXR), was recently implicated in intestinal antibacterial defence and barrier function. The aim of this study was to investigate the therapeutic potential ...

此外，此前研究发现缺失 NR2F6 可增强 T 细胞的抗肿瘤反应，尤其是在免疫检查点抑制期间。本研究进一步表明，在 NK 细胞中缺失 NR2F6 对于缺乏有效 T 细胞表位或下调 MHC-I 表达以逃避免疫监视的肿瘤可能具有重要意义，为联合治疗干预提供了潜在途径。然而，NKp46 表达增强在自身免疫性疾病如系统性红斑狼疮（SLE）中的作用仍有待进一步研究，需要深入探讨 NK 细胞上 NKp46 ...

Olive oil bioactives, including MUFAs, polyphenols, and triterpenoids, modulate gene expression linked to insulin sensitivity ...

The total area burned in the recent Los Angeles fires is comparable to that of the primary destruction zone of a strategic ...