Therefore, drug targets that act in the brain, specifically on the central component of the trigeminovascular system, the TCC, would seem to be ideally placed to modulate this nociceptive pathway ...

Preventive therapies targeting calcitonin gene-related peptide (CGRP)—ie, monoclonal anti-CGRP or anti-CGRP receptor antibodies, which are injected subcutaneously or intravenously, and gepants, which ...

The prelimbic (PrL) cortex is vulnerable to insult from adolescent alcohol exposure and receives input from the basolateral amygdala (BLA) while sending projections to the ventrolateral periaqueductal ...

Gastric pain has limited treatment options and the nociceptive ascending pathway remains largely unclear. Here, the authors identify a glutamatergic tetra-synaptic NTS–LPB–PVT–PL circuit ...

Gastric pain has limited treatment options and the nociceptive ascending pathway remains largely unclear. Here, the authors identify a glutamatergic tetra-synaptic NTS–LPB–PVT–PL circuit ...

One alternative strategy for pain treatment is to intervene in the molecular pathways regulating TRPV1 function during pathological processes ... Controlling the pain relief phase helps to confine the ...

New research suggests that a non-image-forming retinal pathway and signals from the ... The difficulty in explaining the origin of migraine nociception could be rooted in widespread convergence ...

NYU Grossman School of Medicine is a founding member of the Consortium of Accelerated Medical Pathway Programs (CAMPP). Formed in 2015 with eight medical schools and funded by the Josiah Macy Jr.

For we are labourers with God: ye are God's husbandry, ye are God's building (1 Corinthians 3:9). The Bible does not say we are labourers for God, but we are labourers (fellow-workers) with God. He ...

The parabrachial nucleus (PBN) receives nociceptive information from the spinal cord and trigeminal ganglia and relays it to higher brain regions involved in pain perception via the ...

Objective Integration of nutritional, microbial and inflammatory events along the gut-brain axis can alter bowel physiology and organism behaviour. Colonic sensory neurons activate reflex pathways and ...