or to a central mechanism, reflecting the sensitization of central nociceptive neurons to mechanically evoked input. Successful neuropathic pain management requires the definition of precise ...

Treatment with XG005 resulted in statistically significant and clinically meaningful reduction in post-surgical pain ...

This issue hosts review and research articles considering mechanisms of plasticity of primary afferent ... the SCI community is chronic above-, peri-, and below-level neuropathic pain, much of which ...

Pain is one of the most debilitating symptoms ... including a fundamental mechanism-based approach, a clinical mechanism-based approach and an evidence-based approach. Moreover, interindividual ...

Impact and progress Frontiers' impact Progress Report 2022 All progress reports ...

From Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville Campus, Victoria, Australia (R.H.R.) Division of Endocrinology and Metabolism (E.D.A.), ...

Enzyme mechanisms are the chemical transformations, and the steps within them, generated by enzymatic action on substrates. The mechanism of enzyme catalysis is similar in principle to other types ...