Immunotherapy. 2011;3(9):1075-1086. MIP-1β release has also been observed for CD56 neg NK cells from patients with HCV infection. The above results suggest that the aberrant CD56 neg NK subset ...

此外，此前研究发现缺失 NR2F6 可增强 T 细胞的抗肿瘤反应，尤其是在免疫检查点抑制期间。本研究进一步表明，在 NK 细胞中缺失 NR2F6 对于缺乏有效 T 细胞表位或下调 MHC-I 表达以逃避免疫监视的肿瘤可能具有重要意义，为联合治疗干预提供了潜在途径。然而，NKp46 表达增强在自身免疫性疾病如系统性红斑狼疮（SLE）中的作用仍有待进一步研究，需要深入探讨 NK 细胞上 NKp46 ...

Some recent studies have provided examples of NK cell involvement in allograft tolerance. NK cells possess allele-specific inhibitory receptors that could interact with specific alleles of HLA and ...

By connecting with its tumor-associated overexpression ligands, such as MICA, MICB, and ULBPs, NKG2D, an activating NK cell receptor can modulate the cytotoxic capability of NK cells against ...

Unlike CAR-T cells, NK cells don’t need genetic modification to recognize a specific threat — they act broadly without customization. However, some NK companies, such as Fate Therapeutics and Cytovia ...

In this study, the normal biology is two important cell surface molecules involved in NK cell function. First, Carlsten’s team focused on a receptor that binds the molecule E-selectin. In people with ...

A group of scientists in China has revealed a novel mechanism whereby a short form of IL-18, generated by caspase-3 cleavage ...

Immune checkpoint receptors, which are inhibitory cell surface ... which significantly contribute to NK cell exhaustion. Since these compounds have a consistent effect on antitumor immunity ...

We are interested in further understanding the molecular and cellular mechanisms involved in NK cell development, effector function, and generation of memory. We have recently demonstrated that ...

The polymorphic nature of KIRs and their ligands adds a layer of complexity to NK cell interactions with tumor cells. Moreover, other inhibitory receptors like CD94/NKG2A, PD-1, TIGIT, and TIM-3 ...