Astrocyte transcriptomics: APOE isoforms caused differential changes, suggesting possible impairment of proteostasis and autophagy in APOE4 astrocytes. Microglial response: Apoe-deficient microglia ...

If the relative contributions of astrocytes and microglia are not properly ... astroglial-enriched cultures is likely to be mainly microglial in origin. This review considers cell culture protocol ...

indices of Ki-67 and cleaved caspase-3 immunoreactive astrocytes and microglial cells were assessed at different proximate time points after the onset of acute excitotoxic lesion. Application of ...

An experimental nasal spray has helped clear toxic protein buildups in the brains of mouse models of Alzheimer's. Its ...

Summary: Astrocytes, critical brain cells, are often lost in neurodegenerative diseases, but recent research highlights the promise of astrocyte transplantation to restore brain function. These ...

The brain, traditionally considered an immune-privileged organ due to the blood-brain barrier (BBB), has its own sophisticated immune defense system.

Fig. 5. Suppl A. Homeostatic hiPSC-derived microglial cells in the mouse retina do not affect local retinal cells. Entire section images showed GFAP, GS, RBPMS, and Iba1 staining for astrocytes, ...

Targeted therapies that modulate microglial and astrocytic activity show promise in mitigating neuroinflammation. Anti-inflammatory agents, immunomodulatory approaches, and neuroprotective strategies ...

According to a new study, hemp extract containing cannabidiol (CBD) and cannabidiolic acid (CBDA) may help mitigate the ...

Spray targets overactive immune cells in the brain Microglia and astrocytes play a key role ... s such as beta-amyloid plaques, increased microglial activity, and inflammation by the age of ...