In these assays, a protein of interest is assayed against a complex mixture of full-length ... such as integral membrane proteins, transcription factors or strongly acidic proteins.

The gut of animals is a complex ecosystem consisting of trillions of bacteria and other microorganisms that are unique to every individual. Infants can inherit their first gut bacteria through vaginal ...

G protein-coupled receptors (GPCRs) are integral membrane proteins with seven membrane-spanning helices. Upon binding to a ligand – which can range from small molecules like cyclic AMP to ...

Sea lettuce is a sustainable protein source, and researchers have tripled its extraction efficiency, paving the way for ...

SARS-CoV-2 disrupts cholesterol metabolism by using its ORF3a protein to sequester cholesterol in lysosomes, reducing BMP ...

(Nasdaq: VCNX), a clinical-stage biotechnology company pioneering a differentiated approach to treating cancer and neurodegenerative disease through the inhibition of SEMA4D, today announced the ...

Research indicates that cannabis use causes cellular damage that increases the risk of highly cancerous tumors by disrupting ...

The findings identify key proteins in this destructive process – p62 and CHMP7 – revealing ... envelope integrity and disrupt the normal activity of the cellular machinery responsible for nuclear ...

In this study, our results uncover the function and mechanism of CHMP5 in the regulation of cell senescence and bone formation in osteogenic cells. Deletion of Chmp5 causes endolysosomal dysfunction ...

Scientists discovered that SAM plays a critical role in the production of methylmercury, a highly toxic compound that ...

In recent years, the integration of biophysical techniques with molecular simulations and artificial intelligence (AI) has revolutionized our understanding of biomolecular and cellular properties.

As part of an international collaboration, Fred Hutch scientists provided structural information that helped reveal how two ...