Macroautophagy is a process in which cellular contents are degraded by lysosomes or vacuoles and recycled. Double-membraned structures called autophagosomes enclose cellular material and then fuse ...

引言衰老是生物体经历的系统性功能衰退过程，与神经退行性疾病、代谢失调和癌症等年龄相关疾病密切相关。蛋白质稳态（proteostasis）的丧失是衰老的重要分子特征之一，而自噬（autophagy）在维持细胞稳态及调节蛋白质降解过程中起核心作用。自噬主 ...

Several autophagy pathways operate within a cell, including macroautophagy, microautophagy and chaperone-mediated autophagy. The selective destruction of ribosomal subunits through autophagy ...

We discuss the detailed events of autophagy later. The mechanisms by which macroautophagy is regulated were first studied in yeast, and many autophagy-related genes (Atg) were identified. Many of the ...

For a long time, lysosomes were considered as mere waste bags for cellular constituents. Thankfully, studies carried out in the past 15 years were brimming with elegant and crucial breakthroughs in ...

Background Biological ageing is one of the principal risk factors for neurodegenerative diseases. It is becoming increasingly clear that acceleration of DNA methylation age, as measured by the ...

Objective Accumulation of mitochondria underlies T-cell dysfunction in systemic lupus erythematosus (SLE). Mitochondrial turnover involves endosomal traffic regulated by HRES-1/Rab4, a small GTPase ...

Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research (NIPER), Ahmedabad 382355, Gujarat, India Department of Pharmacology and Toxicology, College of ...

Human α–lactalbumin made lethal to tumor cells (HAMLET) is the first member in a new family of protein–lipid complexes that kills tumor cells with high selectivity. The protein component of ...