For example, MDM2 binds to TP53 mRNA ... The biological effects of p53 pathway variants at the molecular level in primary cells or in vivo still need to be determined. The design of genetically ...

Malfunction of the p53 pathway is an almost universal hallmark ... such as gene amplification of key negative regulators of p53, MDM2 and MDM4. Germline TP53 mutations are found in individuals ...

In tumors where p53 is not mutant p53 function is still reduced due to defects in signaling pathways that regulate the E3 ligases Mdm2/Mdm4. Here Lane?s team pioneered work on peptide inhibitors of ...

These two pivotal studies will be multicenter, open-label, randomized, registrational Phase III studies: first one is to evaluate the efficacy and safety of APG-2449 versus platinum-based ...

This important study reports, with convincing evidence, that a long non-coding RNA disrupts the activity of the tumor suppressor p53 to contribute to the growth and therapeutic response of ...

as well as candidates aimed at IAP and MDM2-p53 pathways, and next-generation TKIs. Ascentage Pharma is also the only company ...

Despite decades of experimental progress, the control rate of AD remains poor, and more precise deciphering is needed for potential therapeutic targets and signaling pathways involved. In recent years ...

The child and humility; importance of forgiveness; marriage and divorce; rich young ruler; laborers in the vineyard; request of James and John. Then came Peter to him, and said, Lord, how oft shall my ...

The transcription factor p53 is one of the most widely studied tumor suppressor genes and has been referred to as the “guardian of the genome” due to its pivotal role in the regulation of signaling ...