Disappearance of SUMO-modified Mdm2, which is observed upon radiation, may thus be a prerequisite for DNA-damage-induced accumulation of p53. Figure 2: Destructive pathways: SUMOylation of Mdm2 ...

Over the past two decades, the idea of targeting transcription factors to combat malignancies has turned into a clinical reality. Targeting oncogenes and their interactive partners is an effective ...

Over the past two decades, the idea of targeting transcription factors to combat malignancies has turned into a clinical reality.

Malfunction of the p53 pathway is an almost universal hallmark ... such as gene amplification of key negative regulators of p53, MDM2 and MDM4. Germline TP53 mutations are found in individuals ...

Western blot assays were performed to identify the presence of p53, phospho-p53, and murine double minute 2 (MDM2) isoforms in plasma samples. Densitometric analysis was used to determine the ...