They showed that these stimuli also decreased AMPA receptor-associated GSK3β activity, suggesting that induction of LTP could inhibit GSK3β and therefore inhibit LTD. Indeed, the authors showed ...

This may explain why LTP is more readily induced in young animals ... therapy (and indeed a drug that prolongs the opening of AMPA receptors is already being tested in humans).

Knockdown of Rab4 reduced spine volume change while knockdown of Rab10 boosted it and enhanced functional LTP (in KO mice). To test Rab effects on AMPA receptor exocytosis, the authors performed FRAP ...

Activation of kainate (KA) and α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) glutamate receptors (GluRs) increase interleukin-6 (IL-6) release and cause arthritic pain, respectively. We ...

Studies of synaptic plasticity have shown that stimuli too weak to induce long-term potentiation induce short-term potentiation ... Enhanced long-term and impaired short-term spatial memory in GluA1 ...

However, some studies have challenged the central role of ketones because medium-chain fatty acids, which are part of a commonly used variation of the diet (the medium-chain triglyceride ketogenic ...