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自噬成分LC3通过LFA1转运响应外向内信号调节淋巴细胞粘附
伴随自噬体的形成,自噬衔接蛋白(如 p62)募集泛素化底物。与经典自噬途径不同,由外向内信号传导不会刺激 p62 聚集或 LC3 - II(LC3 的脂化形式)的降解(补充图 7a,b),而 LC3 本身的脂化对于 LFA1 依赖的淋巴细胞黏附很重要(补充图 7c,d)。为了进一步 ...
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