ORLANDO -- More than 40% of patients with longstanding prurigo nodularis (PN) had significant improvement within 3 months of ...

SASP factors secreted by senescent cells activate the JAK-STAT3 and NF-kB pathways in non-senescent tumor cells, promoting proliferation, therapy resistance and SASP spreading. Senescent tumor cells ...

Janus kinase (JAK) inhibitors look to be a good treatment option for the newly recognized, rare autoimmune disease known as ...

The Janus kinase (JAK)/signal transducer and activator of transcription (STAT) signaling pathway plays a key role in immune response and inflammation. More and more studies demonstrated that JAK/STAT ...

Since the end of World War II, the business plan of American universities has included two key principles that now are undergoing rapid disruptive change: Student-athletes participate in college ...

为解决 JAK - STAT 基因错义突变研究的空白问题，研究人员对比 COSMIC 和 All of Us 数据库开展研究。结果发现突变分布特征及三类突变。该研究有助于理解突变影响，推动个性化医学发展，推荐科研读者阅读。 在基因的奇妙世界里，有一种叫做单核苷酸多态性 ...

Protein concentration was determined using the BCA protein concentration determination kit. Western blot was used to detect apoptosis and protein expression of JAK2/STAT3 signaling pathway, as ...

A few decades ago, hotels were supreme. They had strong relationships with their customers, who were deeply loyal to particular hotels they trusted. But that has changed with the rise of online ...

That change was linked to a rise in a modified form of cholesterol known as oxysterol. Lowering oxysterol, in both animal models and human stem cells, freed the trapped ABCA1 and restored the pathway ...

Dizal’s golidocitinib is the world’s first drug targeting the JAK/STAT pathway for the treatment of relapsed/refractory peripheral T-cell lymphoma. It received priority review and conditional ...