These results demonstrate that the axis of interleukin 12 and gamma interferon provides ... rat monoclonal antibody against mouse IFN-γ (clone XMG1.2) and was developed using secondary biotin ...

Patient 2, who did not develop a positive skin reaction after chemotherapy with IFN, interleukin-2 and 5-fluorouracil, partially responded to vaccination therapy after a delay. The study ended in ...

Gene signatures identified a prominent response to interferon gamma (IFN-γ), as well as to tumour necrosis factor, interleukin-6 and hypoxia, in both humans and mice. Mass cytometry confirmed that ...

Interleukin-18 (IL-18) is a classical member of the IL-1 superfamily of cytokines ... Independently of this IL-1-like signaling, IL-18 also specifically induces IFN-γ production, driving the Th1 ...

Consequently, any autoimmune or inflammatory disease reveals a Treg insufficiency. As low-dose interleukin-2 (ld-IL2) expands and activates Tregs, it has a broad therapeutic potential. Aim We aimed to ...

Phosphorylated STAT1 homodimers translocate to the nucleus and bind to the gamma activating sequence (GAS ... upregulating MHC class I and MHC class II expression, and modulating interleukin 12 (IL-12 ...

By utilizing quantitative and qualitative models, we discovered that soluble factors secreted by human monocytes potently inhibit SARS-CoV-2-induced cell-cell fusion in viral-infected cells. Through ...

Merck & Co/MSD has agreed to buy Pandion for $1.85 billion, bolting on a pipeline of drugs for autoimmune and other immunological disorders headed by interleukin-2 (IL-2) based therapy PT-101.

Nintendo Switch 2 is finally confirmed. After literal years of unverified rumors, dubious leaks and copious amounts of online speculation, Nintendo has lifted the lid on its next-generation ...

综合这些研究结果，研究人员得出结论：IL6 和 IFNγ 的基因变异对 ESKD 贫血儿童的 ESA 治疗效果有显著影响。IL6 作为炎症的关键介质，会刺激铁调素的产生，减少铁的可用性，阻碍红细胞的生成。比如，GC 和 CC 基因型的患者，由于 IL6 水平升高，炎症干扰了铁代谢，导致对 ESA 的抵抗性更强。同样，IFNγ 的 TT ...

belle.shiga-med.ac.jp Background and aim: Interleukin (IL) 17 is a cytokine which exerts strong proinflammatory activities ... After incubation with the primary antibody, sections were reacted with ...