IL-2 and IL-15 receptor complexes share the β and γ chains, and the γ chain is used by IL-4, IL-7, IL-9 and IL-21. IL-2 attaches to only IL-2Rα with low affinity, to IL-2Rβ and IL-2Rγ ...
Summary: Tocilizumab is a novel monoclonal antibody that competitively inhibits the binding of interleukin-6 (IL-6) to its receptor (IL-6R). Inhibiting the entire receptor complex prevents IL-6 ...
The main competitor will be Dupixent, which is an IL-4 receptor alpha antibody. Longer-term data also look favorable, with Ebglyss having higher maintenance of response at week 52 (these are also ...
This important study provides solid in-vivo evidence that CCR4 regulates the early inflammatory response during atherosclerotic plaque formation. The authors propose that altered T-cell response plays ...
Luke Altmyer's fourth touchdown pass of the night, a 4-yarder to Pat Bryant in overtime, led Illinois to a 31-24 win over No. 22 Nebraska on Friday in Lincoln. Illinois (4-0, 1-0 Big Ten ...