It is a characteristic of certain rare syndromes, including Prader-Willi syndrome and Bardet-Biedl syndrome, and is also associated with hypothalamic obesity, which arises from damage to the ...

Multiple neuropeptides have been identified that appear to modulate pathways within the hypothalamus to control appetite. Identifying potential therapeutic targets for the treatment of obesity ...

Researchers say the findings highlight the importance of early intervention for obesity to protect brain health, particularly in females.

Because the human brain is difficult to study, much knowledge about the hypothalamus is based on studies in mice and forms the basis for research on anti-obesity drugs. "We know that so-called GLP ...

Aardvark’s lead candidate ARD-101 is being investigated in a Phase III study for hyperphagia in Prader-Willi syndrome.

In the hypothalamus, GPCR-expressing neurons regulate feeding behavior and energy ... Understanding these mechanisms is beneficial for developing novel therapeutic drugs and strategies for obesity ...

and mental health disorders. Clinical obesity is a chronic disease due to obesity alone and characterized by signs and symptoms of ongoing organ dysfunction and/or reduced ability to conduct daily ...

Phase 2 obesity co-administration study with MC4R agonist bremelanotide plus GLP-1/GIP dual agonist tirzepatide Database lock completed Topline data readout ...

Jan. 27, 2025 — A study shows that patients with obesity and fatty liver-related cirrhosis who had bariatric (weight-loss) surgery significantly lowered their future ... Signposting Children to ...