The hypothalamus plays a crucial role in the regulation of feeding, reward and other motivated behaviors. Elucidating neuronal circuits within the hypothalamus using animal models can expand our ...

This review highlights the key areas of research in the hypothalamic control of appetite. The hypothalamus consists of several nuclei that integrate peripheral signals, such as adiposity and ...

The researchers also explored how the PMd interacts with other parts of the brain, particularly the ...

and medicine (how can we target specific brain signals to treat common diseases?). A key focus is on pan-CNS-projecting "brain orchestrator" circuits radiating from the hypothalamus, and postulated to ...

At one end of the circuit are special neurons in the arcuate nucleus (Arc) region of the hypothalamus that pick up hunger signals such as the hormone leptin, which is produced by fat cells.