As noted above, stellate cell activation is the central event in hepatic fibrosis. Activation consists of 2 major phases: (1) initiation (also called apreinflammatory stage) and (2) perpetuation ...

Abstract & Introduction Activated Hepatic Stellate Cells as a Target For Antifibrotic Therapy Current Therapeutic Approaches in Liver Fibrosis Concluding Remarks References Many treatments ...

The HepaStem cells have immunomodulatory properties, similar to other MSCs, and act on the hepatic stellate cells that drive hepatic fibrosis. These immunomodulatory, antifibrotic, and liver ...

This review discussed experimental mouse models used in the pre-clinical study of liver fibrosis regression, a pivotal ...

Moreover, the cells act on hepatic stellate cells, a key driver of hepatic fibrosis. This gives such liver-derived progenitor cells anti-inflammatory and antifibrotic properties. Recognizing the ...

Additionally, in liver fibrosis, HMGB1 activates hepatic stellate cells (HSCs), contributing to the fibrotic response, while ...

Liver diseases, both acute and chronic, continue to pose significant clinical challenges due to high morbidity and mortality ...

Learn about HMGB1's crucial role in liver diseases, its pathways and therapeutic potential that can treat liver diseases.

The two other genes, MAT2A and MAT2B, are active within a second kind of liver cell called stellate cells, which also play a role in fibrosis. All three genes "code" for different proteins ...

2017 Exosome mediated intercellular communication between hepatitis C virus infected hepatocytes and hepatic stellate cells. J Virol. 91(6). pii: e02225-16. PMCID: PMC28077652 Sasaki R, Devhare PB, ...

Carisma Therapeutics Inc. (CARM) presented promising preclinical data on engineered macrophages for treating liver fibrosis at the ...