Next, the activated IL-1β and IL-18 can release into the extracellular in a manner independent of the gasdermin family and mediate the inflammatory cascade. However, GSDMD can be cleaved into ...

Division of Vascular Surgery and Endovascular Therapy, University of Florida College of Medicine, Gainesville. (M.J.J., R.M.H., H.L., L.C., M.L.S.D., G.S., G.C., G.R ...

Additionally, we explore the potential applications of GSDMs in both innovative and established antitumor strategies. Figure 1 Canonical inflammasome pathway and non-canonical inflammasome pathway ...

Background and aims—Cytokine production by endothelial cells has, for practical reasons, been chiefly studied in human umbilical vein endothelial cells (HUVEC) but, because tissue-specific differences ...

This valuable study on strategies used by Pseudomonas to subvert hots immunity identifies a new immune evasion strategy. The study presents solid evidence on the cleavage of VgrG2B by Caspase 11 and ...

c-Met signal inhibition by SU11274 suppressed TNF-α stimulation-enhanced CXCL16 production by RA FLSs in a dose-dependent manner. Furthermore, HGF induced HUVEC tube formation by 1.8-fold. Conclusion: ...