UM171在肌醇己基磷酸的帮助下，作为分子胶诱导KBTBD4-HDAC1/2相互作用，从而促进协同抑制因子降解。 揭秘 UM171：改写蛋白调控 ...

However, the molecular basis underlying the transformation from metaplastic to cancerous cells remains poorly understood. Conclusions Our findings highlighted that KLHL21 loss triggers STAT3 ...

As an immune and metabolic organ, the liver affects the progression and prognosis of sepsis. Despite the severe adverse effects of sepsis liver injury on the body, treatment options remain limited.

A wide plethora of intervention procedures, tissue plasminogen activators, mechanical thrombectomy, and several neuroprotective drugs were reported in stroke research over the last decennium. However, ...

Pulmonary arterial hypertension is a disease of the pulmonary vasculature, resulting in elevated pressure in the pulmonary arteries and disrupting the physiological coordination between the right ...

Article subjects are automatically applied from the ACS Subject Taxonomy and describe the scientific concepts and themes of the article. Alpha-enolase (ENO1) is a glycolytic enzyme that reacts with ...

Mechanistic studies revealed that upregulated HLF transcriptionally enhanced interleukin 6 (IL-6) expression and intensified signal transducer and activator of transcription 3 (STAT3) phosphorylation, ...

Guangdong Provincial Key Laboratory of New Drug Screening, NMPA Key Laboratory for Research and Evaluation of Drug Metabolism, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou ...