Infections by multidrug resistant organisms (MDROs) are a global health threat with a worrying increasing trend. In fragile ...

By analyzing E. coli protein levels, scientists found a surplus of membrane shuttle proteins that may play a role in antibiotic resistance.

Three of these six pathogens are antibiotic-resistant Gram-negative bacteria. Recently, antibacterial drugs against ESBL-producing Gram-negative bacteria accounted for ∼15% (2 out of 13 ...

LpxC inhibitors are emerging as a promising class of antibiotics targeting Gram-negative bacteria, which are notorious for their resistance to many existing antibiotics. LpxC, an essential enzyme ...

Infex Therapeutics, the Alderley Park-based anti-infectives specialist, has been awarded a £1m grant, alongside Germany’s ...

Aztreonam–avibactam is a promising treatment for complicated intra-abdominal infections and hospital-acquired or ...

Cornell researchers have identified a key protein mechanism that helps bacteria expel antibiotics, making them more resistant ...

Antimicrobial resistance (AMR) is a major 21st century global health challenge. Multidrug-resistant Gram-negative bacteria (MDR-GNB) contribute a significant portion of the AMR threat, with an ...

All patients with suspected Gram-negative endocarditis should undergo transesophageal echocardiography (TEE) to confirm the diagnosis and assess for cardiac complications such as intracardiac ...

A study reveals alarming rates of antibiotic resistance in Gram-negative bacteria, highlighting the urgent need for ...