Maintenance of the osteoclast metabolic signature is governed by elevated glutaminolysis. Mechanistically, glutaminolysis provides amino acids and nucleotides which are essential for osteoclast ...

Department of Hematology and Medical Oncology, Emory University, Atlanta, Georgia.

By Pooja Toshniwal Paharia Study reveals that moderate fever temperatures (39°C) improve metabolism, proliferation, and ...

(3) the TCA cycle is altered at multiple checkpoints and accumulates citrate, and the glutaminolysis pathway is not activated. In PAH patients, plasma metabolic and transcriptomic data indicated that ...

“Glucose drives the glycolysis pathway, while glutamine drives the glutaminolysis pathway.” He added: “No tumor, including GBM, can survive without glucose and glutamine. Our study has identified a ...

Alveolar macrophages (AMs) reside in the lower airways and play a crucial role in lung health and response to sterile inflammation and infections. AMs possess remarkable adaptability to different ...

Introduction: The application of ketogenic dietary interventions to mental health treatments is increasingly acknowledged within medical and psychiatric fields, yet its exploration in clinical ...

This led to a notable reduction in the expression of genes associated with glycolysis and glutaminolysis, resulting in durable regression of multiple MYC-overexpressing and highly malignant solid ...