Girls are more often seen than boys, but patients from both sexes have been described (Figure 1). Figure 1: Familial and sporadic cases of gigantism and male and female growth patterns due to Xq26.3 ...
It is caused by microduplications at chromosome Xq26.3, first described in 13 subjects with early-onset gigantism. These microduplications span an area of 500 Kb containing 4 genes. Among these genes, ...