Yale researchers have created "Ochre," a genomically recoded organism that enables the production of synthetic proteins with ...

As key components of biological systems, nucleic acids are major targets in the field of synthetic biology for engineering and studying biochemical pathways and cells. One example is genetic code ...

Synthetic biologists from Yale were able to re-write the genetic code of an organism - a novel genomically recoded organism (GRO) with one stop codon - using a cellular platform that they developed ...

Furin is identified as the key enzyme responsible for cleaving the apelin precursor. Inhibiting this cleavage could serve as ...

A single gene in the shorebird species known as ruffs controls the levels of testosterone in males, and this in turn affects ...

Endosomal recycling is a branch of intracellular membrane trafficking that retrieves endocytosed cargo proteins from early and late endosomes to prevent their degradatio ...

Feb. 7, 2025 — A research team has made a major discovery on how the CUL5 gene affects CAR-T cell therapy, an advanced cancer therapy. The study reveals that reducing the activity of the CUL5 ...

LATS1/2-inactivation and consequent nuclear YAP/TAZ hyperactivation in the mammary epithelium drives the development of a pro ...

Feb. 13, 2025 — Findings from a new study highlight key differences in the gut microbiome of infants with cystic fibrosis (CF) compared to that of healthy infants, and how these alterations may ...

Chemical modification describes the modification, addition or removal, through chemical reaction, of any of a variety of macromolecules, including proteins and nucleic acids. It refers to the use ...

This is an important and solid study that examines the role of TFAM, a protein that helps maintain mtDNA, in mtDNA mutator mice. The authors have demonstrated that TFAM's counteractive role in mtDNA ...