Non-coding parts of a gene, called introns, are typically removed as a gene's DNA is transcribed into an RNA version in a process called splicing. Cancer cells can interfere with splicing to create ...

Scientists Discover New Code Governing Gene Activity Aug. 20, 2024 — A newly discovered code within DNA -- coined 'spatial grammar' -- holds a key to understanding how gene activity is encoded ...

These include structural and chemical changes to the genetic material, binding of proteins to specific DNA elements to regulate transcription, or mechanisms that modulate translation of mRNA.

Dynamic, reversible modifications of DNA and RNA regulate how genes are expressed and transcribed, which can influence ...

A new approach for identifying new cellular RNA targets of snoRNAs uncovered thousands of previously unknown targets ...

Most commonly a mutated gene is replaced with DNA encoding a functional copy. Alternatively DNA encoding a therapeutic protein drug may be introduced. In this paper, a CRISPR-based gene addition ...

After years of setbacks, biotechs are advancing treatments for Huntington’s disease, offering new hope as clinical studies ...

Nov. 25, 2024 — A groundbreaking method to profile gene activity in the living human brain has been developed. This innovative approach opens new avenues for understanding and treating ...

Harry Erba, MD, PhD, professor of medicine at Duke Cancer Institute, chair of the SWOG Leukemia Committee, and co-chair of ...

University of Chicago scientists have expanded our understanding of snoRNAs, discovering their extensive influence on ...

IL-2 stimulation post-transcriptionally enhances splicing of IFNG mRNA in NK cells. Further, NF-κB signaling downstream of the IL-2 receptor is required for IFNG mRNA processing. IL-12 and IL-2 ...