Researchers at Osaka University identified a degradation factor for SREBP1 as essential for maintaining the balance of ...

Researchers have identified ARMC5 as a key regulator of fatty acid balance in adipose tissue. ARMC5 degrades non-SCAP-bound SREBP1, activating it to regulate stearoyl-CoA desaturase (SCD), an enzyme ...

Objective Increased de novo fatty acid (FA) synthesis and cholesterol biosynthesis have been independently described ... Loss of Fasn and its mediated de novo lipogenesis delays but does not ...

Researchers at Osaka University identified a degradation factor for SREBP1 as essential for maintaining the balance of saturated and unsaturated fatty acids in adipose tissue.

Researchers suggest findings represent "a major advancement in developing microbiota-based intervention strategies to improve child health." ...

Free fatty acids (FFAs) and their metabolites are important mediators of lipotoxicity ... FFAs induced upregulation of hepatic MPST protein expression in high-fat diet (HFD)-fed mice and patients with ...

Phosphatidic acid ... free FA delivery to the liver, and increase hepatic lipid content, which are substrates for TG synthesis and, thus, VLDL production. Most evidence supports that omega-3 fatty ...

We show that hepatic lipid content is similar in ob/ob and ob/ob–p55/p75-null mice (Table 1). Moreover, serum transaminase levels are also not significantly different between ob/ob mice with or ...

They fed mice a diet high in soybean protein, which influenced gut bacteria and supported heart health. Analysis showed that this diet increased the production of the short-chain fatty acids in ...

Excitingly, the results from a short-chain fatty acid (SCFA) analysis support our hypothesis ... a controlled environment with a temperature of 24±2°C and a 12-hour light/12-hour dark cycle, in a ...