Here we investigated the pathogenesis of deletion mutant mitochondrial (mt)DNA by generating mice with ... and by using cytochrome c oxidase (COX) electron micrographs to identify COX activity ...

The discovery of its two-dimensional structure was possible thanks to the invention of the electron microscope ... is comparable in size to the mitochondrial DNA of other eukaryotic cells ...

Sample preparation is much easier for an optical microscope than a Transmission Electron ... The mitochondria have been treated with a reagent that suppresses DNA replication, inducing dysfunction ...