This increase in ER capacity is physically achieved by an increase in size of the ER at early stages of autophagy, see figure. If the protein folding demand continues to increase, this will ultimately ...

Inside cells, there exists an extensive system of canals known as the endoplasmic reticulum (ER), which consists of membrane-encased tubes that are partially broken down as needed—for instance in case ...

The ER-phagy receptor FAM134B is initially distributed via the membrane surface (left). Its IDRs move back and forth in a largely disordered manner, like tentacles. The formation of local clusters ...

Cells adjust the expansion and networking of their internal canal system as needed. A process known as ER-phagy ("ER-eating") ...

Cells adjust the expansion and networking of their internal canal system as needed. A process known as ER-phagy (“ER-eating") plays a central role here. During this process, a part of the membrane of ...

remodelling across neuronal subcompartments and decode the substrate selectivity of ER-phagy receptors during in vitro neurogenesis. Single-cell multi-omics of arrested human embryos reveal that ...

Cells adjust the expansion and networking of their internal canal system as needed. A process known as ER-phagy ("ER-eating") plays a central role here. During this process, a part of the membrane ...