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揭开细菌DNA超缠绕的秘密
这一发现更新了几十年来人们对旋转机制的传统看法。这些图像显示,这种酶是一个高度协调的多部分系统,每一部分都以精确的顺序移动,以实现DNA的超盘绕。杜伦大学教授Jonathan Heddle说:“结果表明,在超缠绕过程中,酶的复杂运动部分的确切位置和顺序与我们之前认为的不太一样,这可能会影响我们设计新抑制剂的方式。” ...
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