条件性基因敲除小鼠的设计利用了Cre/LoxP或Flipe/Frt原理。它们都是位点特异性重组酶系统。 Cre-LoxP 系统是一种基于位点特异性 ...

在当今的生命科学研究中，Cre小鼠和Flox小鼠作为重要的转基因小鼠模型，正在为基因功能的深入研究提供强有力的工具。这 ...

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Conditional gene targeting based on excision or inversion of loxP-flanked DNA segments by Cre recombinase is a powerful technology for the analysis of gene function, but unexpected expression ...